Scientists develop a drug that can ‘melt away fat’ and reverse heart conditions

THIS new drug could be a way to treat diabetes and heart disease.

Scottish scientists are currently trialling a new drug that could “melt away fat” inside arteries.

Researchers from the University of Aberdeen have found that a single does of the new drug completely reversed the effects of atherosclerosis – a disease that can cause a variety of heart problems.

This means that this new drug could be a treatment for heart disease, strokes and diabetes.

Atherosclerosis is when plaque builds up inside your arteries. Plaque being made up of fat, cholesterol and calcium will harden over time and cause your arteries to become narrow.

A new drug that can eradicate this disease with a single dose could be groundbreaking.

The trials were conducted on mice who had the disease and after taking the drug had less plaque in their arteries.

The new drugs stops an enzyme called PTP1B which is found in higher levels among people who are obese or those with diabetes.

Professor Mirela Delibegovic and Dr Dawn Thompson from the University of Aberdeen’s Institute of Medical Sciences said: “All humans have some level of atherosclerosis.

“As you age you start to develop these fatty streaks inside your arteries. It is a big problem for people who are overweight or have underlying cardiovascular conditions.”

The drug, trodusquemine, has already been trialled for treatment of diabetes and cancer, but this is the first time it has been used to treat atherosclerosis.

The researchers added: “These have only been tested at pre-clinical level, in mice, so far but the results were quite impressive and showed that just a single dose of this drug seemed to completely reverse the effects of atherosclerosis.”

Since the trial has been so successful on mice, the next step will be to trial on humans.


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