Deadly sepsis could be treated by a new drug that ramps up the immune system to fight back

A new way to treat deadly sepsis infections that works by revving up a patient’s immune system could be on the horizon.

The drug interleukin-7 (IL-7) – is often called ‘the maestro of the immune system’, because it recruits immune cells to help beat infections.

By supercharging the immune system the drug gave patients’ bodies’ the boost needed to prevent organ failure following a sepsis infection, according to a study published in JCI Insight.

The trial, carried out by researchers at Washington University School of Medicine in St. Louis, is especially unusual, because previous research has focused on antibiotic treatments for sepsis infections.

A new way to treat deadly sepsis infections could be on the horizon by revving up a patient’s immune system
The deadly toll of sepsis

Each year there are around 123,000 cases of sepsis in England and it kills around 37,000.

Anyone can develop sepsis after an injury or minor infection but people with weakened immune systems, hospitalised for a long time, recovering from surgery or wounds, or are very young or old are most at risk.

Sepsis and its more severe form called septic shock are among the deadliest problems facing patients in intensive care units.

The conditions occur when the body has an extreme response to infection triggering an overwhelming immune response, ultimately wreaking havoc on the immune system.

Until now patients are given high doses of antibiotics to fight the infection but they often don’t work well and fail to boost the body’s immune defences, leaving patients vulnerable to new infections.

Statistics obtained by MailOnline show that deaths from sepsis are not proportionally even across the UK.

In fact, patients are twice as likely to die from sepsis in some hospitals as they are in others.

Sepsis death rates at Tameside and Glossop NHS Foundation Trust in Ashton-under-Lyne are 55 per cent higher than expected.

At the other end of the scale, sepsis has claimed 39 per cent fewer lives than officials predicted at the University Hospitals of North Midlands NHS Trust.

When compared, it means the chance of dying from sepsis in Tameside is about twice that of a similar patient treated at the Staffordshire site.

WHAT IS SEPSIS?

Sepsis, also known as blood poisoning, occurs when the body reacts to an infection by attacking its own organs and tissues.

Some 44,000 people die from sepsis every year in the UK. Worldwide, someone dies from the condition every 3.5 seconds.

Sepsis has similar symptoms to flu, gastroenteritis and a chest infection.

These include:

Slurred speech or confusion
Extreme shivering or muscle pain
Passing no urine in a day
Severe breathlessness
It feels like you are dying
Skin mottled or discoloured
Symptoms in children are:

Fast breathing
Fits or convulsions
Mottled, bluish or pale skin
Rashes that do not fade when pressed
Lethargy
Feeling abnormally cold
Under fives may be vomiting repeatedly, not feeding or not urinating for 12 hours.

Anyone can develop sepsis but it is most common in people who have recently had surgery, have a urinary catheter or have stayed in hospital for a long time.

Other at-risk people include those with weak immune systems, chemotherapy patients, pregnant women, the elderly and the very young.

Treatment varies depending on the site of the infection but involves antibiotics, IV fluids and oxygen, if necessary.

Source: UK Sepsis Trust and NHS Choices

The results, which came from Professor Sir Brian Jarman, who helped expose the Mid-Staffordshire hospitals scandal, was behind the analysis.

His findings, disputed by the NHS, suggest a ‘postcode lottery’ of care is consigning hundreds, or even thousands, of patients to an early grave.

Small clinical trial involving drug interleukin-7 (IL-7)

A small clinical trial led by researchers at Washington University School of Medicine in St. Louis shows revealed drug interleukin-7 (IL-7) drug holds promise.

The drug’s approach, to rev up the immune system, goes against the grain of earlier strategies that have relied on antibiotics and inflammatory medications to tamp down the immune system.

Senior investigator Professor Dr Richard Hotchkiss at Washington University explained: ‘Mortality rates from sepsis have remained essentially the same over the last 50 years.

‘Hundreds of drugs have been tried and have failed.

‘It may sound counterintuitive when inflammation is such a problem early in sepsis, but our approach is to stimulate certain immune cells to help the patient’s system take control of the infection.’

The trial involved 27 patients aged 33 to 82 severely ill with septic shock at two hospitals in the US and two in France.

Of theses 17 were given a drug made of interleukin-7 (IL-7) called ‘the maestro of the immune system’ because it enhances the proliferation and survival of two types of immune cells CD4 and CD8.

These cells are important because they recruit other immune cells to fight severe infections that can lead to organ failure and death.

The drug interleukin-7 (IL-7) – called ‘the maestro of the immune system’, because it recruits immune cells – could kill beat infections by supercharging the immune system
The other ten patients received the standard treatment.

Co-investigator Professor Dr Edward Sherwood of Vanderbilt University Medical Center in Nashville where some were treated said: ‘Patients who develop the most serious form of sepsis, called septic shock, often have very low counts of these key immune cells

‘We believe that could play a role in the development and course of sepsis because without those cells, patients aren’t able to clear as much harmful bacteria.’

Those who received the drug experienced a threefold to fourfold increase in CD4 and CD8 counts.

IL-7 boosted the adaptive immunity, in which CD4 and CD8 T cells help recruit other immune cells – called macrophages, monocytes, neutrophils and dendritic cells – to kill bacteria that cause infections.

‘Hundreds of drugs have failed’

Prof Hotchkiss said traditional sepsis treatments do not address the critical problem of patients’ severely compromised immune systems.

Without restoring immune function, many patients develop lingering infections and are helpless to fight any new infections.

He added: ‘We know that 40 per cent of patients die in the 30 to 90-day period after the initial septic infection.

‘Their bodies can’t fight secondary infections, such as the blood infections and staph infections that can develop later on because their immune systems are shot.

‘By strengthening adaptive immunity with IL-7 and increasing the numbers of CD4 and CD8 cells available to help fight infections, we think this approach can make a big difference.’

The new strategy of using IL-7 to boost the immune system is being tested in cancer patients and other critically ill patients to boost their survival rates.

A larger clinical trial is planned for sepsis patients.

Source: http://www.dailymail.co.uk/health/article-5477603/Sepsis-treated-new-drug-revs-immune-system.html

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